NorthWest Biotherapeutics Inc (NWBO)

[flipper44]

PLX-3397 would be an interesting combination with DCVax. PLX-3397 was determined to have a very significant attribute back in 2014. What was it?

Here, maybe a quiz will help.

1. What immune cells make up approximately 15% of all cells in the brain?

2. What immune cells can make up to 50% of a tumor?

3. Do these cells behave more like macrophages or some other cell?

4. Can all these immune cells be temporarily eliminated from the brain safely?

5. Can these immune cells actually suppress an immune response?

6. Why would one want to temporarily eliminate these cells from the brain?

7. How fast can these cells be replenished in the brain after complete removal?

7. Have preclinical studies shown that PLX3397 + DCVax are effective against nonresected tumors?

8. What patient group was never allowed into the DCVax-L trial? Could a group like this benefit from the above combination?

9. Dr. Prins and Dr. Liau both seem to think more needs to be done for active progressors and people with inoperable tumors. These are people who are either rapid/indeterminate progressors, only partially resected or can't be resected at all.