Anavex Life Sciences Corp (AVXL)

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There continues to be an overwhelming belief that either amyloid-beta (A-beta) deposits or tau protein tangles are the cause of Alzheimer’s. Yes, those neuron abnormalities can be easily detected with microscopic examination of affected brain tissue. They are universal in those with Alzheimer’s.

But there is increasing evidence that A-beta deposits or tau tangles are merely a result of the root cause(s) of the disease, not the causes themselves.

The real question is this: What neuron abnormality allows A-beta deposits or tau tangles to occur?

In fact, elimination of either of these may simply fail to stop the progression of the disease. And getting the immune system or other cellular mechanism to selectively degrade and clear A-beta and tau proteins will be a daunting task; one likely to incur any number of unknown severe side effects. The clearing agent, somehow, must cross the blood/brain barrier and then ensconce itself inside affected neurons — without changing or affecting other normal neuron chemistries. Personally, I doubt this approach can or will work.

Instead, the root cause of Alzheimer’s neuron dysfunction must be addressed — and that’s exactly what 2-73 does. It restores normalized mitochondrial interactions and connections with the endoplasmic reticula, allowing the neuron to function normally. In virtually every neurological disease, mitochondria and endoplasmic reticula fail to properly connect, causing dysfunction in both organelles. In neurons, the results are always bad. Anavex 2-73
simply (without side effects of note, at low concentrations) uniquely reconnects mitochondria with the adjacent endoplasmic reticula.

Problem solved.