NorthWest Biotherapeutics Inc (NWBO)

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"We showed that an increased estimated TIL content prior to therapy was associated with prolonged TTP and OS. All very long-term survivors in this trial had estimated TIL content in the top quartile. The correlations between estimated TIL content and TTP and OS argues that estimated TIL content in the initial tumor specimen may be used to select patients for DC vaccination and may be applicable to other immunotherapies as well. In contrast, TIL content was not associated with survival in patients who were not treated with immunotherapy. Thus, our data suggests that the use of TCR sequencing to predict such survival indices may be directly relevant only for patients undergoing immunotherapy treatments such as DC Vax." -- Cancer Immunol Res. 2016 May;4(5):412-8. doi: 10.1158/2326-6066.CIR-15-0240. Epub 2016 Mar 11

http://www.ncbi.nlm.nih.gov/pubmed/26968205