NorthWest Biotherapeutics Inc (NWBO)

[Doc logic]

Doktornolittle,

That is a good reminder but just to clarify, circulatory DCs are known to seek out inflamatory signaling pathways as do migratory cancer cells, at least by by all appearances. If "activated" DCs are drawn more to the same sites as migratory cancer cells then this is where certain immune system interactions can take place as DC signaling modifies the environment. This then leads to identification of cancer antigens, perhaps by various modalities, depending on the type of activation. DCs and macrophages are looking for dead or dying cells. If inflamatory signaling is not coupled with dead or dying cells then DC antigen presentation is impaired. Only certain immune cells bumping into metastatic cancer cells or drawn to congregated DC signaling might have a chance to identify and destroy these cancer cells before they move out of the circulatory system and attach to tissue. Many metastatic cancer cells do appear to be killed this way but escape occurs anyway in most cases. A certain type of DC and its proper activation might help with circulatory and binding site recognition of antigens by regular T-cells without the need for migration to the lymph zone by the DCs. I don't want to get too specific here for obvious reasons but NWBO has mentioned how DCs can be activated in some of their documents and some types of activation would allow this to occur.