NorthWest Biotherapeutics Inc (NWBO)

[Doktornolittle]

Adds the info that Proneural can become Mesenchymal and that in general there might be transitions between types. But still not super clear just what constitutes a mesenchymal tumor. If mesenchymal denotes the migratory form then there is no such thing as a purely mesenchymal tumor... only tumors with some mesenchymal cells, whether those cells hang around or immediately migrate?????

If one assumes they migrate soon after transition then a mesenchymal tumor would be any tumor that is generating mesenchymal-radiation of sorts. Sort of like evaporation.

This mesenchymal-radiation would be a survival advantage (for the tumor) so that a weaker tumor might survive with this going on, that would not survive without this going on. So that if DCVax-L were to kill the migrating mesenchymals-radiaton, as you speculate, it could tip the balance for the rest of the tumor cells toward death. Maybe.

Restated... a tumor that would normally not quite survive immune system attack might survive because it is constantly moving, via this mesenchymal radiation, perhaps away from local cytokine dominance by the good immune system. Thus killing off the migrating mesenchymals could be enough to allow the immune system to kill off the tumor.