NorthWest Biotherapeutics Inc (NWBO)

[Doktornolittle]

"During migration [after/during epithelial to mesenchymal transition], cells overcome this problem either by creating a dense array of short-branched filaments as found in lamellipodia, or by bundling filaments as found in filopodia."
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If this "dense array of short-branched filaments" has exposure to the outside world, then I would agree that this is consistent with some possible transient increase in vulnerability to immune system attack, like a turtle's legs when it walks, as you said. Just the increased surface area due to the "dense array of short-branched filaments" might increase vulnerability, but maybe something more dramatic, as you suggest. Maybe a reduction in immune blockade function on that large, specialized, transient surface area; combining our guesses as to why DCVax-L may be more effective on mesenchymals.

You are saying that the mesenchymals do more of this fast movement than the other three subgroups?