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pharmeng

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pharmeng

Re: None

Wednesday, 06/15/2016 7:09:39 PM

Wednesday, June 15, 2016 7:09:39 PM

Post# of 34618
Some clinical evidence that FRa is a viable target in ovarian cancer.

Immunogen reported phase 1 results for their FRa targeted ADC in May.
The median PFS and ORR in patients with high/medium FRa expression was 6.7 mo and 44% compared to 4.2 mo and 17% in pateints with low FRa.

I think this bodes well for the TPIV/Astra combo study since Immunogen showed some correlation between FRa expression level and response rate. TPIV has only shown immune response in their trials so far, and no efficacy, but this is helpful data to show the target may work.



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