Anavex Life Sciences Corp (AVXL)

[TrueTrades]

Nice work Mikesc! Now, if you could get them to explain how A2-73 differs from Alvameline (Lu 25-109)...that would be great.

https://en.wikipedia.org/wiki/Alvameline

https://www.researchgate.net/publication/13602158_In_vivo_muscarinic_cholinergic_mediated_effects_of_Lu_25-109_a_M1_agonist_and_M2M3_antagonist_in_vitro

http://www.sciencedirect.com/science/article/pii/S0024320597010874

Is the lower dosage of A2-73, which has a much longer duration and half-life, not producing the extreme chollergenic side effects while providing a disease-modifying effect over an extended time?

Dr V, et al certainly seem to have expounded on the research in their development of our compounds.

http://www.ncbi.nlm.nih.gov/pubmed/12714934

Again, the specifics of allosteric, selectivity, affinity, heterodimerization, sodium channels, etc seem to be (perhaps) the keys to making compounds work as intended (hypothesized).

I continually find support for the Anavex thesis as well as a particularly intriguing Cinderella story. How anybody could critisize the CEO is beyond me. Knight in shining armor is more like it...for the little redheaded princess!
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