Anavex Life Sciences Corp (AVXL)

[TrueTrades]

In support of that post I must link to some good reading. I'm a big fan of the ALZForum

http://www.alzforum.org/therapeutics/rember-tm

http://www.alzforum.org/news/research-news/will-tau-drug-show-its-true-colors-phase-3-trials

http://www.ncbi.nlm.nih.gov/pubmed/9794144

This excellent paper illustrates how A2-73 being an M1 agonist and M3 antagonist may decrease the phosphorylation of tau upstream from the MB hyper-phosphorylation prevention MOA. The modulating of S1 receptor to stabilize intra-cellular calcium levels may also keep the tau from becoming extra-cellular and phosphorylated in the first place:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3683623/

TauRx is likely eager to put their compound(s) before the FDA ahead of Anavex. Their data supports the Anavex thesis, where as Anavex' may render theirs unnecessary, so we might be the "stiffer" of the competition. Our dose max right now is 50mg once daily, while LMTX is 60mg three times daily and causes nausea if not taken with food and diarrhea.

Saftey will be the key, and that being the primary objective of the 2 year extension tells me that the drug is most obviously working.

andthentheres3-71!
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