NorthWest Biotherapeutics Inc (NWBO)

[Doktornolittle]

"Gene-Modified T Cells, Vaccine Therapy, and Nivolumab in Treating Patients With Stage IV or Locally Advanced Solid Tumors Expressing NY-ESO-1 (NYM)"

If they find a way to get the costs down, the T-Cell therapies sound wonderful. But the last I looked, they were only being used on blood cancers. The last I looked was maybe 18 months ago, but my vague recollection is that they experienced cytokine storms (out of control immune responses that endanger the patient) when attempting to use these therapies on solid tumor cancers. For that reason, I don't see why they would want to mix such with a blockade inhibitor. I can't see the blockade inhibitor quelling the cytokine storm, but rather, exposing the patient more directly to the storm.

Unless... the Blockade Inhibitor allows them to use less of the T-Cell therapy, resulting in less of a cytokine storm.

New areas of development, so who knows. I should not pretend to know. Even if everything I say here is correct, these things seem well worth trying out for patients that have no other options. Maybe they will hit a magic cocktail. Maybe it will involve a T-Cell therapy. Maybe a Dendritic Cell therapy. Maybe a DCVax.