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Saturday, May 28, 2016 10:50:01 AM
Of course not clear whether a lymph node could survive such a transplant, but no reason to assume it would not. You just try it. They remove lymph nodes all the time to check patient status, since there are roughly 500 in the body, they consider loss of 1 not a big deal, apparently.
A key question I posed to you which you answered indirectly; I would like to push for a direct answer:
Are you saying that when macrophages consume activated DC's, they preferentially consume the ones activated with self antigen over the ones activated with neoantigen? I kind of doubt that, but if you say you know such to be true I will give it some credence.
Not the same issue as macrophages preferentially consuming DC's that are not activated over those activated. The activated DC's travel faster than the ones not activated, so the slow ones are probably more vulnerable to macrophage attack than the fast ones. This wouldn't even require the macrophages to know the difference. At any rate it is a different issue than the macrophages distinguishing whether the DC activation is by a self antigen or a neoantigen.
I am almost certain that the DC's do not know the difference or behave differently based on whether they are activated by a self antigen or a neoantigen. Whether the macrophages can make the distinction is a different question, but I doubt that they can.
The neoantigen activated DC's are not faster than the self-antigen activated DC's.
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