Avid Bioservices Inc (CDMO)

[jb_118]

BOT-

I'm fairly new to seriously looking at PPHM, but one thing that bothered me a bit is that I can't see any examples of log reduction numbers in their animal models. (I'm aware there isn't an HCV animal model.)

I don't know how to equate "lethal"/"non-lethal" with log reductions in viral titers. At all. I suspect that the relationship would depend on the antigen, the species being tested, the initial viral load and the dose of the MAB at the very least. I don't know how to relate accute hemmoragic fever lethal/non-lethal data in pigs to a chronic HCV viral titer reductions in humans.

I also don't see the connection between 70/30 chimeric and 70% effective and 30% effective. I do agree it should be at least as effective in humans, but I don't think you can quantify the effectiveness by the % chimeric, especially when the data are on different pathogens. It was 50% effective in preventing death in pigs. Would a fully human MAB be 100% effective? Maybe, but not because it was fully human.

I'm still left wondering what sort of viral titers to expect from the repeat dose study. If anybody knows of viral titers from any of the PPHM animal work I'd like to learn.