Wednesday, May 18, 2016 6:13:52 PM
Here's a doctor's take on today's PR -
Big news for the epilepsy world!
by dadofmarcmax • 45 minutes ago Flag
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Ok, so infantile spasms (new nomenclature is "epileptic spasms") mostly occurs between 4 months -7 months of age but can occur at any age and presents as sudden flexion of arms,legs with tonic posturing. The EEG shows a pattern called hypsarrythmia and the spasms show a classic slow wave followed by generalized paroxysmal fast activity with electrodecrement. It is thought to be the result of some sort of insult to the brain either structurally or related to a genetic defect.....many causes. Furthermore, spasms are thought to occur as a result of an inflammatory cascade, hence ACTH as a strong corticosteroid works (strong anti inflammatory properties). I have always stated that 2-73 works to stop neuroinflammation and with this news; we may have a new and less potentially dangerous medication than ACTH to treat spasms.
West syndrome (where spasms are seen), if not controlled early after diagnosis leads to devastating developmental consequences.
This is BIG news in the epilepsy world. Again, this is why I'm so heavily invested in AVXL; the potential to change neurology as I know it is huge! I'm glad I'm in early.
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