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Doktornolittle

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Doktornolittle

Re: CherryTree1 post# 61706

Sunday, 05/15/2016 10:37:07 PM

Sunday, May 15, 2016 10:37:07 PM

Post# of 702441
I believe they added subgroup approval options at the same time that they expanded the trial. This presumably being before any unblinding of the data.

If they added specific subgroups before any unblinding, including to the DMC or the PEI or anybody who might leak back hints, then I don't think it has the same statistical degradation that it would otherwise have.

Just adding subgroups does effect the statistical significance, but nothing like the effect of adding subgroups after some kind of feedback.
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