NorthWest Biotherapeutics Inc (NWBO)

[Doc logic]

flipper44,

The more I go back and read the press release by NWBO the more I think that the Phase 2 trials being partnered are more related to L than Direct. The announcement is deliberately vague and the term Phase 2 makes us think Direct because that is the next step for the Direct trial. This could easily have been made clear but it was not. We know that NWBO can say nothing about L that seems promotional in any way. We also know that more is known about L than Direct. Safety, dosing and MO have been established for L so no Phase 1 is needed and the mesenchymal form of cancer is found in some cancer types more than in others. This would be a good reason to target 3 specific cancers using 3 different combos to see how each combo responds in different settings. I also thought Dr. Prins made a comment about partnering with L but not Direct at this point in time. The separate discussion of upgrades to Direct seem to point to working on getting Direct right and verified first before trying to partner it. Best wishes.