Anavex Life Sciences Corp (AVXL)

[apostrophe]

re: "You've overstated"

Perhaps a bit. If we define "cure" as taking one pill and becoming completely healthy again forever, admittedly, that is probably not achieveable. Also, nothing can bring back cells that have actually died, back to life.

Compared to our ancestors, we have a lot of "weird" stuff in our environment, water, food supply. Then, there's a possible heredity factor. Something that takes decades to induce subtle cell poisoning (e.g. nitratiion) may be near impossible to single out or it may even turn out to be something that can no longer be done without, to keep a modern population of 7 billion fed somehow. Maybe it would be better to think of 2-73 as an antidote to whatever it is that is poisoning the cells or making them susceptable.

With AD, memory loss has occured because the brain cells for memory have become sick and are no longer able to function properly. With current standard of care drugs, cells continue to sicken and die. In contrast, taking Anavex 2-73 is curing the cells of their sickness as evidenced by the restoration of lost memory. What is unprecedented is that, many of these cells had been otherwise given up for dead. Furthermore, the curative effect of 2-73 is being sustained.

Cells that are near death could be expected to take the longest to come around and I would expect a tapering off of rate of change as normalcy is approached. Most things like this, tend to follow a natural log curve. And as Stephen Hawking once said, "You can't go farther North than the North pole". It's just that the AD North pole now appears to be achievable lot farther North than anyone dared to hope, before the Anavex approach was implemented.

I guess the preferred term nowadays is "disease modification". But as the saying goes, " if it looks like a duck, walks like a duck, and quacks like a duck..."