NorthWest Biotherapeutics Inc (NWBO)

[Doc logic]

flipper44,

The CD3+ T-cell count seems to reflect immune response level while neutrophil count seems associated with immunosuppression. When immunosuppression exceeds certain values then this becomes reflected in longer term prognosis with treatments currently available. The hope here is to turn this indicator almost upside down with immunotherapy mono or combo treatments. Remember that these indicators correlate only to current treatment regimens and this correlation does not necessarily predict correlation to all possible treatment types. You expressed this in expressing the hope that improved treatment schedule with L could lead to better outcomes for most if not all patients and I believe this to be the case as well. I also believe that earlier administration of L as a primer could be helpful as well since synergies are known to exist between immunotherapy and chemo/radio therapy potentiation. Less cancer cell repair would happen after surgery and perhaps additional exposed antigens could be picked up as well.