NorthWest Biotherapeutics Inc (NWBO)

[Doktornolittle]

"DCs, if properly activated, can manipulate their environment to get antigens to present themselves that would otherwise remain hidden."

This is the part that is news to me. I didn't know that was one of the behaviors that could be modulated.

Seems likely that some mutations disable the basic protein presentation function altogether. If so the cancer would be extremely hard or impossible to detect; unless the cells have redundant mechanisms for protein presentation based on different genes so that any given mutation can't disable the function altogether; and (sounds like you are saying) some of those redundant modes are only set in motion by the right cytokine environment, while the more standard mode is always at work unless mutated out of existence.