NorthWest Biotherapeutics Inc (NWBO)

[Doktornolittle]

DOC: If a tumor manages to hide a number of mutated / non-self antigens I understand that the DCVax-L lysing + DC exposure would sniff those out. What I don't understand is how the resulting T-Cells would then find their targets?

Is the reasoning that the T-Cells don't need antigen match at the surface of the tumor cell in order to do damage. Ie that they penetrate better than DC's ?

It seems the T-Cells do infiltrate the tumor... but that is interstitial, is it not? So if the antigens are not presented... the T-Cells don't actually penetrate the Tumor cells looking for antigen do they? Could they do that and then get back out without damaging the cell? I wouldn't guess so, but it sounds like you likely know, and do not have to guess.