NorthWest Biotherapeutics Inc (NWBO)

[Doktornolittle]

Regarding BI/CM +DCVax combination therapies. I haven't followed every Blockade Inhibitor / Checkpoint Modulator clinical result but there are clinicals where the efficacy was not great, and there were clinicals where the side effects were horrific. Were there clinicals where there were great results (ie 25% CR where chances were next to nil) and without the large percentage of side effects which include death?

I am hoping that mixing these BI/CM drugs with immunotherapies such as the DCVax's allows either safer BI/CM drugs to be used or lower dosages resulting in lower side effects yet through synergy with the immunotherapies, greater efficacy. This reduction in side effects doesn't get brought up often, so hoping to spark such conversations.

Understood; that if a CI takes a 5% 2 years survival and improves it to a 25% CR with demonstrated 25% 5 year OS, then horrible stats on side effects for a large but minority population of patients is tolerable. But if you can match or exceed that efficacy and also drop the rate of serious side effects, then that is far better, of course.

What would be the best possible news in my opinion would be that NWBO has been thinking along these same lines and has purchased a low side effect BI that shows great synergy with DCVax-Direct in early studies, even just animal studies. How could they afford such? Maybe such a BI does not have a high price tag because it did not show great efficacy as a monotherapy.