NorthWest Biotherapeutics Inc (NWBO)

[Doc logic]

flipper44,

TILs can include M2 macrophages and T regulator cells as well to varying degrees. These are immunosuppressive as is the hypoxic environment where many cancer stem cells are conserved. Unprimed DCs do not regulate M2 macrophages or Tregs well because they do not initiate a strong enough immune signaling response or one that is long enough to overcome it's weaker response to inflammatory signaling they initially responded to. They can not stay in this tumor environment for very long and also meet immunosuppressive resistance to at the tumor draining lymph nodes when they manage to migrate there with antigen presenting capacity. In total, this prevents a "highly educated" and motivated immune response even when educated TILs are present because critical targets are in a submerged position unless and until a sufficient immune inflammatory response is created.