NorthWest Biotherapeutics Inc (NWBO)

[Doc logic]

ae kusterer,

Leukopenia after chemo/radiation is desirable in most patients. The reason is that Tregs are depleted along with the others. Fresh start so to speak. In some patients, however, this leads to a permanent reduced white blood cell count. This is not good. Those whose cell counts recover also see Tregs recover at this point unless IL-2 levels are controlled. Thus selectivity with the use of an IL-2 blocker favors recovery of white blood cells without the Tregs. There is also evidence that antiviral vaccines given prior to DC vaccination improves DC migration. Lots of good data out there to give us hope that we are closer than ever to controlling cancer or eradicating it. Best wishes.