NorthWest Biotherapeutics Inc (NWBO)

[Doc logic]

flipper44,

B+ is correct. There is a subset of DCs that are sporadically produced in some patients that are more potent. These apparently became more potent by maturation process. Recreating this maturation step for all patients is the hope. Fountain of youth so to speak.

Multiple targets creates greater opportunity for systemic response as higher levels of circulating educated and memory immune cells will be present to hunt down their targets.

The 2 week interval is critical as the tumor microenvironment forces DCs to become circulatory like scouts looking for a target instead of generals managing the fight and the microenvironment with their own signaling. Once they leave the PD-1 response begins to prevent further benefit from intervention.