NorthWest Biotherapeutics Inc (NWBO)

[Doc logic]

flipper44,

You are correct. Dr. Prins also mentioned using monoclonal antibodies " like" anti PD-1 in conjunction with DC therapy to eliminate tumors. Now if the tumor microenvironment causes DCs to revert to circulatory DCs that move away from the tumor environment in less than 2 weeks, how often do you need to inject new DCs to keep cytokine control of macrophage subset M2 from causing immunosuppression while tumor load is still present? This is why I lamented about Direct injection spacing in Phase 1 on Seeking Alpha. The conservative nature of the spacing kept results deliberately suboptimal with a treatment (DCs) that has a strong safety history. Some have even categorized it as a placebo. I am looking forward to what this "grapefruit juice" that can control immunosuppressive macrophages can do in Phase 2.