NorthWest Biotherapeutics Inc (NWBO)

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Time for another hint as to why CXCR4 is an important target. In adults macrophages generally exhibit a primary function of consuming or phagocytizing their targets. In prenatal to neonatal situations macrophages are principally involved in the process of creating new vascular pathways to support growth. Many types of cancer are able to signal at least some macrophages to revert back to their original function to support cancer growth with new vasculature. When this function of cancer cell signaling is interupted, new vascularization in cancer can be interupted. Guess what important and basically non alternative pathway many cancers use for this signaling to macrophages.