Anavex Life Sciences Corp (AVXL)

[LGL8054]

ANAVEX 3-71 completely reversed the deficit observed in transgenic rats (p<0.001), which performed similarly to wild-type rats.

ANAVEX 3-71 demonstrated anti-inflammatory properties, compared to control (p<0.05), which may also have relevance in Alzheimer’s disease.

“The data from this study further validates the belief that ANAVEX 3-71 may have significant utility in the treatment of Alzheimer’s disease. This study examined potential long-term effect of the compound following a five-week hiatus from dosing, which suggests the potential for disease modification – something we have not often seen,” said Professor Claudio Cuello, Professor at the Department of Pharmacology and Therapeutics, McGill University, Montreal, Canada and main author of the study. “This preclinical study provides a variety of improvements in disease progression, including anti-inflammatory properties in aged rats, a test subject that more closely reflects the disease model in Alzheimer’s patients and which we hope to see repeated in human subjects.”

“This body of data of ANAVEX 3-71, in addition to our clinical candidate, ANAVEX 2-73 suggests that our approach of targeting the complex pathology of Alzheimer’s disease further upstream may have the potential to address the areas of unmet need for individuals living with this disease,” said Christopher U. Missling, PhD, President and Chief Executive Officer of Anavex.