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Friday, March 11, 2016 9:17:15 AM
Your line of questioning is correct. RNA technology seems to hold greatest promise where RNAi (intereference) technology works to help block reproduction of faulty proteins. This is specific single target technology for diseases like MS. The multi target diseases like cancer and HIV might both be able to be managed by drug cocktails like are used for HIV but are probably best controlled by immunity. This comes from breaking down, blocking or reversing bariers or their sinals, attacking targeted non self antigens and then developing long term T and B memory cells. The immune system can be trained to do this without knowing all the specific targets which explains the hope placed in immunotherapy. Memory T-cells alone still need to get past Tregs and any other established bariers to targeted antigens like are found in solid tumors. There is a possibility that engineered T-cells plus additional therapies can be used to eventually create this same effect, DCs by themselves can be trained to create the environment for this to happen.
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