NorthWest Biotherapeutics Inc (NWBO)

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Clinical Study - Has the survival of patients with glioblastoma changed over the years?
British Journal of Cancer 114, 146-150 (19 January 2016) | doi:10.1038/bjc.2015.421

R M deSouza, H Shaweis, C Han, V Sivasubramiam, L Brazil, R Beaney, G Sadler, S Al-Sarraj, T Hampton, J Logan, V Hurwitz, R Bhangoo, R Gullan and K Ashkan

Abstract
Background:
Over the last decade, the approach to the management of brain tumours and the understanding of glioblastoma tumour biology has advanced and a number of therapeutic interventions have evolved, some of which have shown statistically significant effects on overall survival (OS) and progression-free survival in glioblastoma. The aim of this study is to compare survival in glioblastoma patients over a 10-year period (1999–2000 and 2009–2010).

Methods:
A retrospective cohort study was performed. Identification of all histologically confirmed glioblastoma in a single centre in years 1999, 2000, 2009 and 2010, and production of survival analysis comparing 1999–2000 and 2009–2010 were achieved.

Results:
A total of 317 patients were included in the analysis (133 in year 1999–2000, and 184 in year 2009–2010). Cox regression analysis showed that the survival was significantly longer in patients in years 2009–2010 than those in 1999–2000 at P<0.001 with HR=0.56, confidence interval (CI) (0.45–0.71).
The 1- and 3-year survival rates were 20.7% and 4.4%, respectively, for patients in 1999–2000, improving to 40.0% and 10.3%, respectively, for patients in 2009–2010.
The comparisons between the two groups in survival at 1, 2 and 3 years are all statistically significant at P<0.001, respectively. The median OS was 0.36 and 0.74 in 1999–2000 and 2009–2010 groups, respectively.

Conclusions:
Over this period, OS from glioblastoma has increased significantly in our unit. We believe this is due to the institution of evidence-based surgical and oncological strategies practised in a multidisciplinary setting.

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http://www.nature.com/bjc/journal/v114/n2/full/bjc2015421a.html