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Post# of 699694
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Doc logic

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Doc logic

Re: flipper44 post# 54595

Monday, 02/22/2016 4:08:50 PM

Monday, February 22, 2016 4:08:50 PM

Post# of 699694
flipper44,

My understanding is that those thresholds appear to be the result of specific monocyte to DC maturation process. DCs act as scouts, sentries and messengers as well as generals. Various environmental factors, growth factors and inflammation signals cause specific types of maturation of monocyte precursors and DC response. Signaling interference can prevent a completely controlled DC response which is why the specific parameters you lsited are required for the observed response. Certain types of DCs are better at controlling this interferrence. Sorry but don't want to get too specific here. There are people who have spent lifetimes working on this and they deserve to have the light shine on their work when they are ready to present it.
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