NorthWest Biotherapeutics Inc (NWBO)

[Doc logic]

Pyrrhonian,

Correct me if I am wrong here but this study that you responded to koman about shows that later psPD appears to respond to TMZ better and these are being placed into the main trial. This is the opposite of what I thought I remembered was happening but then a light bulb went on or I just got sucker punched lol.

Early progressers are being removed either by actual determination or by indeterminate status and they do not respond well to TMZ. Some of the early psPD patients are being removed by way of psPD or indeterminate determinations as well and are also lower end responders of their group to TMZ. You and AVII appear to be arguing that this DCVax-L trial has been cherry picked to prove that extended use of TMZ will prove beneficial for a majority of patients and I agree. I also think that studies showing synergy between DC vaccines and TMZ indicate that treatment arm DCVax-L patients will have at least a 2 month OS benefit over SOC by the end of this study because of earlier acting synergy on lower tumor burdon. What say you?

By the way, the respect is mutual. I'm a truth miner. There is always more rock and dust than gold so you just need to keep digging. "He who seeks the truth with all his heart will find it." Best wishes.