NorthWest Biotherapeutics Inc (NWBO)

[beachlifeisfun]

I'm not so sure. First, the enrollment ramp has been such that many of the 300+ were enrolled in the last two years. Second, have you forgotten that they did re-power the trial? They knew in 2014 that the PFS hurdle was going to be very close and lowered the bar.

Pure speculation. You have no idea why they re-sized the trial and you have only a few clues as to the enrollment ramp. I also have a speculative answer...they re-sized it to buy time to ramp up for pending approval. The statement that 300+ were enrolled in the last two years is idiotic, since they reached the 66 event trigger back in December of 2013...I'm quite certain that 66 did not consist of the entire trial population...and the information arm could not have enrolled >50 without enrolling a good number of others into the trial.

Phase 1 and phase 2 were small samples comparatively. Some of these issues were probably not visible until they achieved a larger cohort in phase 3.

They went straight to the P3 for a reason...

BTW, if the premise that the pseudos are causing problems with the trial were true, then that would have shown up in the DMC review and they would likely have ended the trial due to safety concerns.