Anavex Life Sciences Corp (AVXL)

[blu_1]

Go to fig. 4 which is donepezil MMSE scores. At 6 weeks the change is +0.5 and at 12 weeks less than +1.0. That is for 5 or 10mg dosing of donepezil. Now, compare that to 2-73. Avg MMSE at 5 weeks was +1.5 and for those on highest doses of 2-73 it was more than 80% likely they'd have an improvement of at least +2.0 at 5 weeks. Impressive.

In the 2-73 trial, all but 7 were also on donepezil. But they'd been on it for awhile, so was it still exerting any beneficial effect? Maybe alone no, but maybe a synergy with 2-73 breathed some life back into donepezil? IDK.