Anavex Life Sciences Corp (AVXL)

[bebopagogo]

_Synergy_ of Anavex 2-73 and donepezil is described in Tangui Maurice's new paper. I have the same impression as circa1762 here with regards to it not being clear to the examiner the different methods of action and this paper (which wasn't in the list of references suggested to the examiner) seems to clarify this as synergy is more than just obvious, additive behavior. The paper is titled "Protection by sigma-1 receptor agonists is synergic with donepezil, but not with memantine, in a mouse model of amyloid-induced memory impairments." and the abstract can be found at http://www.ncbi.nlm.nih.gov/pubmed/26386305

From his conclusions in that paper:

"Finally, we also analyzed the combination between ANAVEX2- 73 and donepezil and memantine. We also found with this drug, currently under phase 2a clinical development [84], a clear synergic effect with donepezil. Collectively, our data suggested that the anti- amnesic and neuroprotective effect of selective 1R agonists, or non-selective drugs like ANAVEX2-73, against amyloid toxicity is effective in combination with donepezil. A new, synergic, mode of action could be proposed that may boost the therapeutic efficacy of each drug."

I'm not sure why this reference was not listed other than it is a new publication, pre-published electronically in Sept 2015 but for the January 2016 issue of the journal.