NorthWest Biotherapeutics Inc (NWBO)

[Doktornolittle]

RK's quotes of ancient LL articles include statements that there will never be an immunotherapy that can deal with a bulk tumor. This statement foreshadows problems with Direct as much as L. However:

1) Linda Lau qualifies this statement as potentially biased because she is, first and foremost, a neurosurgeon.

2) That was before blockade inhibitors. And NWBO is going to be using at least one blockade inhibitor in at least one of the cohorts for the phase 2 trials for Direct. Speculation is that they will partner, and use somebody else's blockade inhibitor. I hope that is not the case, and I worry that no big pharma will want to lend them such for testing. NWBO is not wanting to be bought out. For that reason there is little incentive for a BP to lend them their blockade inhibitor... unless it becomes clear that they can't beat NWBO, so they best join NWBO. Of course there is always the incentive of making money off of the sales of the blockade inhibitor. What I am saying is that incentive would not be as strong as the desire to see NWBO dead, unless they cave in to the eventuality that NWBO is not going away.

I hope NWBO finds an approriate blockade inhibitor or inhibitors for sale, and purchases them. That is more their style, and simplifies the situation. I don't undertand why there can be different formulations for inhibitors of the same blockade type, but there apparently can be. I believe there are multiple versions of PD-1 and PD-L1 inhibitors. I hope there are some left for sale, or some similar that are as promising. Maybe down the road such could be used, at some super low concentration, to enhance DCVax-L as well as DCVax-Direct, if such proves necessary.

A blockade inhibitor may sound like something out of NWBO's price range, but I know of a smaller cap company that recently purchased a couple.