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Tuesday, November 17, 2015 7:33:10 PM
On SA a counter to Dr. (10 years ago, IT now) Kline logic is as follows:
"The binding affinity of Anavex 2-73 was performed against "human" s1 receptor, which as conducted by CEREP (Paris,France).
Whereas the high binding affinity of donepezil to sigma-1 receptors ((IC50= 29.1 ± 0.2 nM) was performed on "mouse" brain membranes.
I do not think they can be compared."
An additional thought is it defies logic, why top practising scientists (who are specialists in AD now not juniors 10 years ago) would suggest to use DPZ, as a control Placebo arm, as they have suggested for next P2/3 trials, if DPZ crowds out 273 effects, as his innuendo filled post today said.... this is more of the uncle JC teachings, to his minions, of creating a "new truth" here ... they are very predictable..
Dr. (10 years ago, IT now) Kline's proven suspicious history supporting the cartel in social media, is a further red flag on anything he says....
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