Anavex Life Sciences Corp (AVXL)

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New Anavex 2-73/ donepezil synergy study by Dr. Maurice.

I had posted this on YMB, but there is new paper by Dr. Maurice with the abstract at http://www.ncbi.nlm.nih.gov/pubmed/26386305 relevant to this discussion. Here are the "highlights" from the paper:

• 1 Protein agonists (PRE-084, ANAVEX2-73) are neuroprotective and anti-amnesic in A 25–35-treated mice.

• Their combination with the AChE inhibitor donepezil, but not with the NMDA receptor antagonist memantine, shows synergy for neuroprotective effects.

• The synergy involves combined action at 7 nAChR and 1R.

• Symptomatic effects are purely additive.

In the paper there are results for Donepezil alone, Anavex 2-73 alone, and their combination. (There was also combos with the PRE-084 sigma-1 agonist and memantine)
This paper was accepted in Sept 2015 and will be published in print in the Journal for Behavioural Brain Research, Volume 296, pp 270-278 in January 2016. I think it's also good to see there has been ongoing work in parallel with the current clinical study. The acknowledgments mention "This work was supported in part by Anavex Life Sciences and in part by external resources of the University of Montpellier."