Anavex Life Sciences Corp (AVXL)

[Doktornolittle]

Hooper: Would you please explain this beautiful efficacy chart for AVXL 2-73/Plus. (link below). If not familiar with this chart, please let me/us know and I/we can provide a cluster of chart links all from the guy that generate this chart... not sure his role here other than his apparent crunching of new data from Barcelona.

The text underneath the chart seems to say that the data for 2-73 includes data from MMSE converted to ADAS-Cog. I actually don't remember exactly what either are, but in my vague recollection... I don't remember such tests being interchangeable. Anyway it seems strange and will seem strange to everyone that is not super informed. My guess is that they are indeed interchangeable... but it is not reasonable for me or anyone else to just assume that as we admire the chart.

This chart looks amazing. Super important because it extends out linearily past the point where RVT-101 efficacy has started to wane. But unfortunately, it is very unclear, at least to me, just what the chart is showing.

I assume the early data points for 2-73 include more patients than the later data. In fact, as far as we know, the 18 week data point could be a single patient.

Further, would you please verify that from your understanding, we remain practically blinded as to which patients are taking Donepezil in addition to 2-73, other than knowing that overall, in the end, there will have been 75% with Donepezil, and 25% without.


https://pbs.twimg.com/media/CTelu1cWsAA19YZ.jpg

Aside:

My understanding was that a significant portion of alcohol removal from the blood stream came from evaporation in the lungs. In fact, I believe breathing increases as part of the mechanism to expel alcohol, and that the elevated oxygen levels in the blood that result are part of the alcohol high. This elevated breathing adds to a diuretic effect resulting in dehydration, which feeds back to reduce breathing. So that drinking some water with your booze likely increases your buzz, but costs you more drinks. A question perhaps more properly directed to bourbononmycornflakes.yahoo.message.board.

Oh... my question to you regarding alcohol... If evaporation in the lungs is a substantial contributor to the elimination of alcohol, then wouldn't there be at least a second order dependance of elimination rate on blood concentration? Certainly the rate of evaporation is dependant on blood concentration.