Anavex Life Sciences Corp (AVXL)

[georgejjl]

Regarding the 10 out of 12 positive responders from the July 22, 2015 poster

Remember that for the 12 patients already reported the range of baseline MMSE scores was 16 to 28. What if the two patients that had not responded quite as well at just 36 days were on the low dose of Anavex 2-73 and also had a baseline MMSE score of at or near just 16? That might explain the 10 out of 12 good responders at 36 days into the trial.

"...Initial cognitive EEG/ERP P300 ANAVEX2-73 data of 12 mild-to- moderate Alzheimer’s patients (MMSE 16-28) mostly on donepezil, the current standard of care at end of Part A (day 36)...."

http://www.anavex.com/wp-content/uploads/2015-07-22_Poster_AVXL_Phase_2a_AAIC_July_2015.pdf

Rememer this trial has just two oral doses 30 mg per day and 50 mg per day which were associated with two intravenous doses of just 3 mg per day and 5 mg per day and that the results were only at most 36 days into the trial.

Again, my thoughts are that the two subjects in question may have had baseline MMSE scores of at or near 16 and possibly be given a dose of Anavex 2-73 of just 30 mg per day. It may take them longer than just 36 days in order to see positive responses from Anavex 2-73, but given a longer time on study they may show similar positive responses at 3 to 6 months into the trial.

Good luck and GOD bless,

George