Anavex Life Sciences Corp (AVXL)

[TrueTrades]

I believe the problem with the mouse studies is that mice do not naturally develop amyloid plaques and NFTs. The study mice are treated with a chemical to make them develop the AD symptoms. I think this holds true for all CNSDs as far-as mice toxicology goes. Cancer, for instance, is much easier to correlate between mice and humans, as mice naturally develop cancerous cells.

That is why advancements in early detection biomarkers and new surrogate endpoints for trials is getting the spotlight. All the failed CNSD drugs did great in the mouse models. We can't do reliable testing without more advanced methods. With Anavex and Neuronetrix, we are writing a bit of history towards that aim.

We will get data on human subjects that have been taking the drug for four months. It's a big step.

Basically, our best chance at proof is to get some patients with MMSE scores of 18-20 who go un-changed by more than one point for one year. I believe we will see a significant % of subjects who's MMSE remains un-changed or has actually increased since inclusion in the study. It's gonna be big!

Let's keep the dialogue friendly. We get more accomplished that way.
§AVXLd