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Re: biomaven0 post# 195609

Sunday, 10/04/2015 12:25:47 AM

Sunday, October 04, 2015 12:25:47 AM

Post# of 252334
Peter, this is the last paragraph of AKBA's description of their HIF technology (http://akebia.com/hif-technology/) ...

AKB-6548, our lead compound in development, works by inhibiting HIF-PH, leading to stabilization and increased levels of HIFa, and improved production of hemoglobin and RBCs, while maintaining normal levels of EPO in patients. In addition, we believe that AKB-6548’s mechanism of action provides for the ability to induce a more prominent HIF2a response (as naturally occurs with a moderate increase in altitude), and an enhancement in the normal diurnal variation of EPO, which is the normal rise and fall of EPO during each day.


Jason

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