Biotech Values

[biomaven0]

In mouse models of the genetic disease (Chuvash polycythemia) where HIF is constitutively activated, it looks like it might be HIF-2alpha that is the culprit for late onset fibrosis and pulmonary hypertension, with HIF-1alpha being protective.

http://www.pubfacts.com/detail/20197624/The-von-Hippel-Lindau-Chuvash-mutation-promotes-pulmonary-hypertension-and-fibrosis-in-mice.

See also:

http://www.ncbi.nlm.nih.gov/pubmed/23264599

I vaguely remember that someone saying the AKBA drug hits HIF-2Alpha more - not sure if that is correct or not.

Peter