Friday, July 10, 2015 11:22:31 AM
The German protocol references both Ph I studies and their IND #s. As well as the Ph III IND.
Not sure what you mean by "is included on both the TLR agonists." You mean with? If so yes, in one of the two studies NW references for DCVax-L they used them. In the other, smaller one, they did not. The study you quote here compares patients treated with DCVax-L + TLR agonists (not done in Ph III btw) with a group treated with GAA loaded DC alone. This is one of the reasons drawing distinctions between these two groups is confounded. The GAA group did not receive TLR agonists. They also as a group had a lower K score. And the GAA group is very small--just 6 patients. So I can't really take those comparisons seriously. And in fact I'm surprised UCLA tried. Feels almost like they are being promotional, don't you think?
All of that is fun times but irrelevant to the Ph III. No TLR agonists are used in conjunction with DCVax-L. You had a family member in the trial so you know that, right? Recall any odd additional muscle injections with poly-ICLC?
Freeze thaw is very much an issue in the Ph III. When studies show pointedly that in vitro loading of DC with lysate necrosed via freeze thaw process hinders maturation as well as CD4/CD8 functioning, etc, I wouldn't just dismiss it out of hand. By NW's own admission DCVax-L is inferior. They cite the process causing "confused" DC, and state antigen uptake is only 1/10 as extensive as via the process for Direct.
TLR agonists are supposed to assist in the maturation of DC but according to the study I quoted, freeze thaw lysate loaded DC are resistant to this as well.
Um you're welcome? ;)
I'd offer you advice, but I just don't care about your money, unless you give me money to care about your money. I might even be tricking you with the above post...
Recent NWBO News
- Form 10-Q - Quarterly report [Sections 13 or 15(d)] • Edgar (US Regulatory) • 11/12/2024 09:10:53 PM
- Form 8-K - Current report • Edgar (US Regulatory) • 11/01/2024 09:24:13 PM
- Form 4 - Statement of changes in beneficial ownership of securities • Edgar (US Regulatory) • 09/03/2024 08:01:40 PM
- Form 4 - Statement of changes in beneficial ownership of securities • Edgar (US Regulatory) • 08/13/2024 08:01:24 PM
- Form 10-Q - Quarterly report [Sections 13 or 15(d)] • Edgar (US Regulatory) • 08/09/2024 09:06:07 PM
- Form 4 - Statement of changes in beneficial ownership of securities • Edgar (US Regulatory) • 08/08/2024 08:30:09 PM
- Form 8-K - Current report • Edgar (US Regulatory) • 08/02/2024 02:42:28 PM
- Form 4 - Statement of changes in beneficial ownership of securities • Edgar (US Regulatory) • 07/30/2024 11:49:38 PM
- Biophma Announces Exclusive In License for Dendritic Cell Technology, Sending Shares Higher • AllPennyStocks.com • 06/17/2024 04:40:00 PM
- Form 8-K - Current report • Edgar (US Regulatory) • 06/04/2024 09:11:16 PM
- Form DEF 14A - Other definitive proxy statements • Edgar (US Regulatory) • 06/03/2024 09:22:55 PM
- Form PRE 14A - Other preliminary proxy statements • Edgar (US Regulatory) • 05/22/2024 08:13:36 PM
- Form 10-Q - Quarterly report [Sections 13 or 15(d)] • Edgar (US Regulatory) • 05/10/2024 09:04:57 PM
- Form NT 10-K - Notification of inability to timely file Form 10-K 405, 10-K, 10-KSB 405, 10-KSB, 10-KT, or 10-KT405 • Edgar (US Regulatory) • 03/01/2024 10:04:38 PM
- Form 4 - Statement of changes in beneficial ownership of securities • Edgar (US Regulatory) • 12/02/2023 01:31:35 AM
- Form 8-K - Current report • Edgar (US Regulatory) • 11/16/2023 10:11:54 PM
- Epazz, Inc. (OTC Pink: EPAZ) ZenaDrone Demonstration to Defense Departments of UAE and Saudi Arabia • InvestorsHub NewsWire • 11/15/2023 12:19:31 PM
Alliance Creative Group (ACGX) Releases Q3 2024 Financial and Disclosure Report with an increase of over 100% in Net Income for 1st 9 months of 2024 vs 2023 • ACGX • Nov 14, 2024 8:30 AM
Unitronix Corp. Publishes Its Cryptocurrency Portfolio Strategy • UTRX • Nov 14, 2024 8:05 AM
Avant Technologies and Ainnova Tech Form Joint Venture to Advance Early Disease Detection Using Artificial Intelligence • AVAI • Nov 12, 2024 9:00 AM
Swifty Global Announces Launch of Swifty Sports IE, Expanding Sports Betting and Casino Services in the Irish Market • DRCR • Nov 12, 2024 9:00 AM
Oohvie App Update Enhances Women's Health with Telemedicine and Online Scheduling • HLYK • Nov 11, 2024 8:00 AM
SANUWAVE Announces Record Quarterly Revenues: Q3 FY2024 Financial Results • SNWV • Nov 8, 2024 7:07 AM