NorthWest Biotherapeutics Inc (NWBO)

[Ready4bluesky]

LP sometimes provides hints. For example she hinted several times about the L trial enlargement (with copious amounts of positive spin) before it was officially announced.

In the 10k the tone with regard to Direct seems to have changed. My guess is that the results are not nearly as positive as they had hoped for and we are starting to see a shift from certain plans for "multiple phase 2 trials running in parallel" to "possible" phase 2 trials. This also provides a little legal protection since they have notified the public it is now less likely than was expressed in several statements at multiple investor conferences over the past year.

4 out of 40 partial responses isn't anywhere close to the response rate seen in the pre-clincial mice studies. In light of this, it is logical they would pursue combo options with CI's (which LP has also hinted at), but it doesn't appear they have been able to find a willing partner.

Thus the recent effort to shift the focus back to L, adding more sites, etc.