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Thursday, April 30, 2015 11:19:57 AM
One year following the last cycle of treatment, among 37 patients initially presenting with recurrent or stage IV disease and bearing = 5 neoplastic lesions that were = 3 cm in diameter, 23 exhibited a CR (62.2%), 5 manifested a PR (13.5%), 2 had stable disease (SD, 5.4%) and 7 displayed progressive disease (PD; 18.9%). Among 74 patients with larger and more numerous tumors who presented with recurrent disease, 7 exhibited a CR (9.4%), 3 displayed a PR (4.1%), 2 had SD (2.7%) and 62 (83.8%) had progressed. Finally, among 56 patients that presented with stage IV disease and large tumor burden, 2 were found to exhibit a CR (3.6%)2, 2 manifested a PR (3.6%) and the remaining 52 exhibited PD (92.9%). --http://www.hitvlab.com/images/publications/Hasumi_OncoImmunology_Oct_2013.pdf
It's interesting, I was just recently speculating on short term low dose radiation combined with DCVax.
One thing to remember is the phase I/II DCVax-Direct trial is using partially matured dendritic cells in inoperable tumors. They are not utilizing radiation in this phase I/II. Even so, the very little information we received thus far on DCVax-Direct with only one tumor injected at each procedure during a very conservative dosing regimen is that they are seeing tumor infiltration levels nearly equivalent to the best responding group results above (group 1). It's far too early to know how this translates, without further DCVax-Direct data. Nonetheless, as we now are entering the time when multiple tumors are and/or will be injected in the phase II portion of the phase I/II Direct trial, at optimum dose, frequency and maturity, we may expect the partially matured (not immature as in the above trial) to show what they can do.
I would think the main limitation in the Hasumi trial is the inability to get consistent responses beyond the tumors and tumor areas that were irradiated and injected. I speculate this may have to do with the maturation level and other factors related to the dendritic cells they used.
Still, very encouraging.
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