NorthWest Biotherapeutics Inc (NWBO)

[koman]

Quote "Sounds pretty similar to Direct (including immature DCs) "

Let's just say that this grp's treatment using intratumoral DC vaccine is far more advanced with better chance of success than DIRECT. IF DIRECT could only show something similar to this Japanese grp's study results, then I would have hope that DIRECT works. They did a much better job designing a trial that addresses tumor burden, tumor microenvironment, adjuvant, and other factors to give the intratumoral DC injection a better chance of promoting a stronger immune response.

http://www.hitvlab.com/images/publications/Dr_Hasumi_HITV_Cancer_Journal_Article_April_2011.pdf
5. Conclusions
In summary, combining immunotherapy with radiation was shown to successfully eliminate
metastatic and recurrent tumors on initial treatment in 21 of 26 patients with 13 of the 26 having no
evidence of recurrent disease when evaluated by CT (or PET-CT) at various intervals of follow-up.
The overall disease-free interval of the responding patients at the current time is 377 days. This
remarkable response supports the concept that combinations of conventional anti-cancer therapies and
cancer immunotherapy are worthy of investigation in patients with advanced cancers as well as in
patients that are undergoing primary adjunctive therapy for their disease.