NorthWest Biotherapeutics Inc (NWBO)

[Rkmatters]

My view is Ph I results will continue to impress, but it is a given that they will need to inject multiple tumors to see if they can evoke an immune memory response. Also I expect that one injection site has not been enough to result in complete eradication (which LP imo made clear to us not to expect when she discussed the ovarian pt case study's new small nearby tumor). That said, it's clear to me that one tumor injection has extended survival, and continues to reveal Direct treatment is both promising and effective.

They shared 7 case studies thus far (two in Sept; three in Nov; two in December). From the 7 case studies they've shared, we have yet to hear of the 3 pts to which they reported in June, that had no live tumor cells in their primary tumor so there should be more good news ahead (unless the 3 "no live tumor cell" pts were among these 7 pts but I don't remember that highlight mention in any of the reported studies).

We've also seen an MDA abstract which states they're seeing both local and systemic effect in majority of pts (more than 51!). So again in my opinion, efficacy is being seen and will only get better in Ph II, once they're able to get to apply lessons learned from first phase on optimal maturation, dosing and injection schedule. After all with this Ph I only one tumor has been injected, with a spaced apart schedule (closer is better), with not always the optimal DC maturation, but yet they're seeing local with some systemic effect; so yes, I imagine Ph II will be miraculous as far as extending OS. Plus LP was still able to state back at the Oppenheimer Dec conference, "stay tune for the end of the trial, but they're seeing encouraging survival."