Herpes and Shingles Novel and Emerging Treatments Cimetidine Cimetidine (Tagamet®) is a medication commonly used for treating acid reflux (GERD). It inhibits the production of stomach acid by blocking the signaling pathway for histamine (Hsu 1991). Histamine signaling modulates the immune response to some viruses as well, and researchers have shown that oral administration of cimetidine significantly accelerates the healing of skin lesions and provides pain relief in adults with shingles (Miller 1989). Supporting this finding, an in vitro study performed on cells from 22 people with shingles found that cimetidine improves the body’s immune response, and suggested that healing from skin rash and pain could be accomplished significantly faster (Komlos 1994). Findings from another study, which enrolled 221 patients with shingles, suggested cimetidine may even be efficacious when used during the prodromal period, before manifestation of the characteristic rash (Kapinska-Mrowiecka 1996). In addition, numerous case studies have been published demonstrating that cimetidine may reduce the severity and duration of symptoms of both shingles and herpes outbreaks (van der Spuy 1980; Mavlight 1984; Hayne 1983). For example, one study made the observation that a patient who developed shingles just before starting a course of cimetidine for gastric ulcer experienced a significant relief of shingles symptoms. Based on this finding, which was unexpected at the time, the researchers prescribed cimetidine to several other patients with shingles and oral herpes, and the vast majority of them experienced relief of their symptoms. Another exciting finding was that in one patient with herpetic keratitis, the attacks occurred less frequently and were shorter in duration following cimetidine administration (van der Spuy 1980).
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