Innovation Pharmaceuticals Inc (IPIX): I haven't forgotten about my promise to...

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ShinSekai

Re: TOB post# 81633

Wednesday, 12/10/2014 10:08:25 PM

Wednesday, December 10, 2014 10:08:25 PM

I haven't forgotten about my promise to post more research that adds to the Prurisol picture. The problem is, it's much bigger than I expected.

Other projects, coupled with the explosive growth of nearly every stock I follow, has shifted my focus a bit these past few months so you'll have to forgive me.

One of the most surprising things about this compound is that it is very similar to Lanvis, yet lacks many of the adverse affects typically associated with this cancer drug -often used for psoriasis.

GSK
http://en.wikipedia.org/wiki/Tioguanine

As a plus, it shares some antimetabolite traits with Methotrexate. We kinda know who the winner is already though ;)

http://en.wikipedia.org/wiki/Methotrexate

For those of you who want to get a closer look at G1P3 AKA IFI6
http://www.wikigenes.org/e/gene/e/2537.html

The only blemish in the drugs development, as some of TOB's research pointed out, is that the drugs efficacy was demonstrated in HIV/AIDS patients. As some of you know, SCID mice were used in the preclinical zenograft models. The fact that SCID mice are a great model for HIV/AIDS pathology, makes it hard to say difinitively that the drug works in humans not infected with HIV/AIDS.

I hope investors notice that this drug isn't like the psoriasis drugs of old. Even if the SCID issue causes less of an effect on humans and this isn't really a big 'IF'. I still think an efficacious dose can be found with some alterations.

After today's price movement, I feel most don't understand it's value.

I left off on some promising discoveries, but I'm not very well versed in genetics so that's about where I tapped out.

G1P3 (6-16)

"It is possible that the context of the combined motifs has a profound effect on their function or that small variations in the sequencescan modulate the response(interferon inducible) or even abolish it, as is the case for protein binding for the example of the single base change shown in Figure 6B. While everything is consistent with a major role for the 14 nucleotide sequence, flanking sequences and additional factors may well play an important role in modulating the response."

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC454218/pdf/emboj00138-0087.pdf

Long non-coding RNAs in aging and disease

Overexpression of PRINS is associated with psoriasis susceptibility, with PRINS expression being elevated in the uninvolved epidermis of psoriatic patients compared with both psoriatic lesions and healthy epidermis (Sonkoly 2005).

http://en.wikipedia.org/wiki/Long_non-coding_RNA

Guanosine is required for an RNA splicing reaction in mRNA, when a "self-splicing" intron removes itself from the mRNA message by cutting at both ends, re-ligating, and leaving just the exons on either side to be translated into protein.

Research path