Amarin Corp Plc (AMRN)

[zumantu]

New study suggests R-It success
I was reading this study a 2nd time and became impressed with results in only 30 days. The data appears to suggest the EPA arm of R-It will show significant deviation - perhaps earlier than anticipated

Highlights
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We examined the early effects of EPA treatment in patients with reperfused AMI.
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Early EPA treatment reduced clinical adverse events within a month in AMI patients.
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Early EPA treatment also decreased peak CRP levels after PCI in AMI patients.
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Our findings support the early initiation of EPA after PCI as an adjuvant therapy.

Abstract

Objective
We examined whether early loading of eicosapentaenoic acid (EPA) reduces clinical adverse events by 1 month, accompanied by a decrease in C-reactive protein (CRP) values in patients with acute myocardial infarction (MI).

Background
Acute MI triggers an inflammatory reaction, which plays an important role in myocardial injury. EPA could attenuate the inflammatory response.

Methods
This prospective, open-label, blinded endpoint, randomized trial consisted of 115 patients with acute MI. They were randomly assigned to the EPA group (57 patients) and the control group (58 patients). After percutaneous coronary intervention (PCI), 1800 mg/day of EPA was initiated within 24 h. The primary endpoint was composite events, including cardiac death, stroke, re-infarction, ventricular arrhythmias, and paroxysmal atrial fibrillation within 1 month.

Results
Administration of EPA significantly reduced the primary endpoint within 1 month (10.5 vs 29.3%, p = 0.01), especially the incidence of ventricular arrhythmias (7.0 vs 20.6%, p = 0.03). Peak CRP values after PCI in the EPA group were significantly lower than those in the control group (median [interquartile range], 8.2 [5.6–10.2] mg/dl vs 9.7 [7.6–13.9] mg/dl, p < 0.01). Logistic regression analysis showed that EPA use was an independent factor related to ventricular arrhythmia until 1 month, with an odds ratio of 0.29 (95% confidence interval, 0.09 to 0.96, p = 0.04).

Conclusions
Early EPA treatment after PCI in the acute stage of MI reduces the incidence of ventricular arrhythmias, and lowers CRP values.

to be published in International Journal of Cardiology October 2014

http://www.sciencedirect.com/science/article/pii/S0167527314015812