NorthWest Biotherapeutics Inc (NWBO)

[DrChuck]

I stand by my comment that, IMHO, every time you inject a new tumor, you are essentially creating a new vaccine due to the rapid rate at which mutation occurs.

Exactly. That's how I construed your position. The distal tumors aren't responding to the injection of the DCs into the primary tumor because you need a new vaccine for that. But that's not how it is.

I think you're failing to make a distinction between cancer mutation rate and the expression of that mutation. Any mutation initially is to the DNA in one cell. Usually, mutations, because they are random, kill the cell - it's not functional. But sometimes the mutation is "neutral" and the cell lives but it's still just one in a large crowd of millions. Whatever the expression of that mutation is and whatever way it protects the cell from treatment the patient is undergoing, it's still just that one cell or perhaps by now a large group of descendant cells but still a small part of the overall tumor. The main mass of the tumor is still going to be susceptible to whatever the treatment is. We're not seeing large masses of distal tumor necrosis, therefore we're not seeing a strong systemic response. QED.

You choose to say we're getting glimpses of a systemic response. I say we're seeing a weak response. To a certain extent it comes down to a matter of semantics. Certainly neither of us is claiming we're seeing a strong response. Longusa claims that the data does not show a weak response. Well, that's not something I can argue with because the data just isn't there to draw any firm conclusion. It does appear that injected tumors are getting destroyed or severely damaged, so injecting multiple tumors is definitely the way to go.